Start Your Phage Display Library Today

In today's fast-paced research environment, companies are often faced with critical decisions about resource allocation and expertise requirements. Outsourcing your phage display laboratory needs to Cell Origins presents a strategic advantage that can streamline your research efforts and enhance productivity. By collaborating with industry experts, you leverage specialized knowledge and state-of-the-art technology without the overhead costs associated with hiring and maintaining an in-house phage scientist.  

Driving Innovation

Outsourcing your phage display needs allows your team to focus on core competencies while gaining access to a wealth of experience and innovative methodologies that can significantly accelerate your research timelines. Our dedicated team not only provides reliable and reproducible results but also ensures compliance with the latest regulations and standards, further reducing the risks inherent in research activities. Choose Cell Origins as your outsourcing partner and empower your organization to achieve remarkable scientific results while optimizing resource efficiency. 

Our expert team of scientists at Cell Origins are specialists in phage display technology. With decades of experience and a passion for innovation, our scientists are dedicated to helping researchers achieve their goals in peptide and antibody discovery. Trained at the University of Missouri, the birthplace of phage display, our lead scientists have significantly contributed to the field. Their work has been cited in the Nobel Prize lecture by awardee Dr. George Smith, highlighting our commitment to excellence and advancement in phage display research.

Filling Personnel Gaps for Continuous Employment

At Cell Origins, our expertise spans nearly 40 years in the development of cutting-edge strategies for phage display, peptide and antibody discovery, and ligand optimization. With a team of industry-leading experts in phage display and drug discovery, we are dedicated to ensuring the success of your project. Our comprehensive services include:

Consulting

We provide a wide range of consultancy services such as comprehensive customized research strategies and protocols, enabling the selection of high-affinity peptides and antibodies with exceptional pharmacokinetic profiles . Additionally, we offer expert guidance on lead optimization, enhancing binding kinetics, off-target binding profiles, and tissue excretion redirection for your existing peptides and antibodies. Our research strategies have contributed to numerous impactful publications, projects, and research grants. Learn more here.

Affinity Selections (Biopanning)

At Cell Origins, we address the challenge of generating peptides and antibodies with exceptional binding affinity and pharmacokinetic properties using our MultiTier phage display platform . Our platform utilizes a unique combination of in vitro, in situ, and in vivo screening methods along with advanced automated high-throughput sequencing technologies and in silico analysis to identify high-quality peptides and antibodies. Learn more here.

Peptide & Antibody Screening

Following phage display affinity selections, peptides and antibodies are screened using biomolecular interaction analysis to identify the best leads. Various methods such as peptide- and antibody-arrays, ELISA, AlphaLISA, SPR, and DLS are used for this analysis. Cell Origins develops customized protocols to ensure optimal lead identification, often incorporating cell and tissue analyses.

While phage display affinity selections are efficient, the screening of selected peptides and antibodies is often a bottleneck due to the time-consuming and costly synthesis, production, and purification processes. Furthermore, the limited stability of soluble peptides and antibodies during storage complicates screening and increases experimental costs. To overcome this hurdle, we also provide high-throughput screening of ligand-displaying phage particles to accelerate production while reducing costs and time. Additionally, this screening significantly enhances signal amplification compared to conventional biomolecular interaction analysis methods like ELISA. Learn more here.

Lead Optimization

We conduct lead optimization, including affinity maturation of peptides and antibodies, to enhance binding affinity, specificity, stability, and biodistribution of initial lead molecules. This can be achieved through the optimization and screening of soluble peptides and antibodies or by generating sub-phage display libraries for high-throughput optimization.

Onboarding New Personnel and Setting Up Your Phage Lab

At Cell Origins, we recognize that establishing a new phage lab and integrating new personnel can be a complex undertaking. Our team is here to facilitate a smooth onboarding process, guiding your new hires through the essentials of phage display technology. We offer comprehensive training programs that equip your staff with the necessary skills and knowledge to operate effectively within your new lab environment. 

Moreover, Cell Origins provides expert consultation for setting up your phage lab, ensuring that you have the right equipment, protocols, and systems in place to maximize productivity from day one. Our tailored solutions include practical demonstrations and technical resources which help to instill confidence and competence in your staff.

Ongoing Technical Support

In addition to initial onboarding, our commitment to your success extends into ongoing technical phage display support. Cell Origins delivers continuous assistance through regular consultations, troubleshooting, and updates on the latest advancements in phage technology. With our extensive experience, we can address challenges your team may encounter, enabling them to focus on their research without distraction. By choosing Cell Origins, you not only gain a partner in setting up your lab but also a resource for sustaining your research excellence over time. 

Your Secrets are Safe with Us

At Cell Origins, we prioritize the confidentiality of your research and proprietary information. We understand that trust is fundamental in fostering productive partnerships. That’s why we are more than willing to sign a confidentiality agreement, ensuring that your sensitive data remains protected throughout our collaboration. Moreover, we do not take a cut of commercialization licenses, allowing you to retain full ownership and control over your innovations. With Cell Origins as your partner, you can focus on advancing your research without concern for the security of your intellectual property. 

 Our Team at Cell Origins

The founders of Cell Origins received their training at the University of Missouri, where phage display technology was pioneered. Our scientists have published numerous research articles, including ones cited by Dr. George Smith in his Nobel Prize lecture. Our team of scientists leverages cutting-edge approaches to unlock the full potential of phage display, ensuring success for your research project.

We are a contract research organization and development company with a proven track record in the field of phage display. Let our experienced team help you develop a strategy that optimizes results and provides the best solution for your research needs.

Contact Us to Get Started

At our core, we are dedicated to delivering excellent service that guarantees the success of your project. To begin this journey, please schedule a consultation so we can learn more about your research requirements and how we can assist you. Our  commitment lies in aiding you to receive the most effective solution for your project, propelling your research process forward. Reach out to us today to expand your horizons and schedule a meeting with one of our experienced scientists.